King George III (known as the king who lost America), was born in 1738. King George III's father, the Prince of Wales died when he was young. When George III was 22, in 1760, his grandfather, George II, died. On September 8 th, 1761 he married Princess Charlotte Sophia from Mecklenburg-Strelitz, in Germany and on September 22 nd, 1761, George III became the King of England. George himself was of partial German ancestry. George and Charlotte had 15 children, one of whom, George IV would be the next king.

King George III sat upon the throne of England from 1760-1820. It was on his watch that the American colonies were lost. King George III, after the French and Indian War, had large debts to pay, and thought he could extract the necessary money from the colonies. King George was incensed when the insolent American colonists objected to the taxes being levied, particularly the Stamp Act. When the Stamp Act was repealed, King George flew into a rage. King George thought the colonists should be dealt with harshly for their disobedience and insolence.

Using his profound influence, he pushed through the Townshend Acts, in 1766, taxing many commodity items including tea resulting in the infamous Boston Tea Party. King George was eventually humbled as the American colonies successfully became the United States Of America. Other colonies began to rebel after America's success and King George remained embroiled in one conflict or another for many years. George III inherited more than just the throne. He also had the royal hereditary disease porphyria which had afflicted Mary Queen of Scots. She passed it to her son, King James Iof England.

Porphyria is caused by the insufficient production of hemoglobin. The symptoms are photosensitivity, strong abdominal pain, port wine colored urine and paralysis in the arms and legs. The interruption of nerve impulses to the brain causes the development of psychiatric symptoms. Finally, epileptic convulsions occur and the patient sinks into a coma. George III's first attack occurred in 1765, four years after his marriage to Queen Charlotte. From 1811 to the time of his death in 1820 he became progressively insane and blind.

He spent his time in isolation, and was often kept in straight jackets and behind bars in his private apartments at Windsor Castle. King George III died in 1820, at the age of 82, and his son, George IV, succeeded him. Other members of the far-flung royal family who suffered from this hereditary disease were Queen Anne of Great Britain; Frederic the Great of Germany; George IV of Great Britain -- son of George III; and George IV's daughter, Princess Charlotte, who died of the disease at childbirth.