The Pituitary Gland and Dwarfism The Pituitary Gland is situated at the base of the brain and it produces hormones which control growth. Too large an amount of these hormones causes giantism, a condition where facial features, hands, etc. become abnormally large. Too little causes dwarfism, where the overall stature of a person is very small.
Dwarfism is the condition of being undersized, or less than 127 cm (50 in) in height. Some dwarfs have been less than 64 cm (24 in) in height when fully grown. The word midget is usually applied to dwarfs. Another growth disorder disease is Cretinism which is a result of a disease of the thyroid gland it is the cause of most dwarfism in Europe, Canada, and the United States. Other causes of dwarfism are Down's syndrome, a congenital condition with symptoms similar to those of cretinism, achondroplasia, a disease characterized by short extremities resulting from absorption of cartilaginous tissue during the fetal stage, spinal tuberculosis, and deficiency of the secretions of the pituitary gland or of the ovary.
Causes of pituitary dwarfism may vary. Abnormally short height in childhood may be due to the pituitary gland not functioning correctly, resulting in underproduction of growth hormone. This may result from a tumor in the pituitary gland, absence of the pituitary gland, or trauma. Growth retardation may become evident in infancy and persists throughout childhood. Normal puberty may or may not occur depending on the degree of pituitary insufficiency that is present, which is the inability of the pituitary to produce adequate hormone levels other than growth hormone. Physical defects of the face and skull may also be associated with abnormalities of the pituitary gland.
A small percentage of infants with cleft lip and cleft palate may have decreased growth hormone levels. No ideal treatment has been developed yet for pituitary dwarfism. Replacement therapy with growth hormone is indicated for children who have documented growth hormone deficiency. If the deficiency is an isolated growth hormone deficiency only growth hormone is given. If the deficiency is not isolated other hormone replacement preparations will be required. There are a few complications of pituitary dwarfism.
Some are short stature and delayed puberty development. Creutzfeldt-Jacob disease has been acquired from cadaver derived growth hormone which is no longer available. Synthetic growth hormone is now available which is free of all infectious disease risk. Pituitary dwarfism is a sad disease to see a person have.
Most cases are not preventable. The future may look good for the disease though. Medical breakthroughs are always happening. It may not be easy but doctors are constantly in a lab somewhere working on these terrible disorders and diseases such as pituitary dwarfism.