Bodies Of Nerve Cells In The Brain example essay topic

Alzheimer's Disease Alzheimer's Disease is a progressive and irrevocable brain disease that destroys mental and physical functioning in humans, and perpetually leads to death. It is the fourth leading cause of adult death in the United States, affecting 2.5 to 3 million people each year. The cause has not yet been identified, nor has a cure been discovered, but research advances are being made. To fully be able to understand and fight Alzheimer's Disease, one must know howie affects brain, the part of the body that it takes the largest toll on. Autopsies on manyAlzheimer's Disease sufferers show that a large number of differences were present when comparing a normal brain to their's. There was a loss of nerve cells from the cerebral cortex in the Alzheimer's victim: approximately 10% of the neurons in this region were lost.

Although a 10% loss is relatively minor, and cannot account for the severe impairment suffered by Alzheimer's victims. Neurofibrillary tangles are found in the brain within the cell bodies of nerve cells in the cerebral cortex, and take on the structure of a double helix. Other diseases that have double helixes include Parkinson's disease, Down's Syndrome, and DementiaPugilistica. Scientists are not sure how the double helixes are related in these very different diseases, or if they even are related. Neuritic plaques are patches of clumped material lying outside the bodies of nerve cells in the brain. They are mainly found in the cerebral cortex, but have also been seen in other areas of the brain.

At the core of each of these plaques is a substance called amyloid, an abnormal protein not usually found in the brain. This amyloid core is surrounded by cast off fragments of dead or dying nerve cells. The cell fragments include dying mitochondria, presynaptic terminals, and double helical filaments identical to those that are neurofibrillary tangles. Many neuropathologists think that these plaques ar clusters of degenerating nerve cells, but they are still not sure of how and why these fragments clustered together. Congophilic Angiopathy is the technical name that neuropathologists have given to an abnormality found in the walls of blood vessels in the brains of victims ofAlzheimer's. These abnormal patches are similar to the neuritic plaques that develop in Alzheimer's, in that amyloid has been found within the blood-vessel walls wherever the patches occur.

Another name for these patches is cerebrovascular amyloid, meaning " amyloid found in the blood vessels of the brain". Acetylcholine is a substance that carries signals from one nerve cell to another. Itis known to be important to learning and memory. In the mid '70's, scientists found thatthe brain of a person afflicted with Alzheimer's Disease contained 60% to 90% less of the enzyme choline acetyltransferase (CAT), which is responsible for producing acetylcholine, than did the brain of a healthy person. This was a great milestone in the fight against Alzheimer's, as it was the first functional change related to learning and memory, and not to different structures.

Somatostatin is another means by which cells in the brain communicate with eachother. The quantities of this chemical messenger, like those of CAT, are also greatly decreased in the cerebral cortex and the hippocampus of Alzheimer's victims, almost tothe same degree as CAT is lost. Although scientists have been able to identify many of these and other changes, they are not yet sure as to how, or why they take place in Alzheimer's Disease. They a reso near to completing the mystery of Alzheimer's, but yet still so far away. If treatment is required for someone with Alzheimer's Disease, the Alzheimer " disease and Related Disorders Association (ADRDA), should be contacted. It is a privately funded, national, non- profit organization dedicated to finding a cure and easing the burden off of Alzheimer's victims and their families.

There are more than 160 chapters throughout the country, and over 1000 support groups that can be contacted for help. ADRDA fights Alzheimer's on five fronts: 1) - funding research, 2) - educating and increasing public awareness, 3) - establishing chapters with support groups, 4) -encouraging federal and local legislation to help victims and their families, and 5) -providing a service to help victims and their families find the proper care they need..