Interview With the Vampire is the story of Louis, a Louisiana plantation owner who was unwillingly changed into a vampire, as told by himself to a curious news reporter. Lestat, the vampire who created Louis, used to manage his money. Lestat refused to tell Louis about other vampires or the extent of his powers. By doing this Lestat was able to prevent Louis from breaking away from him and going off on his own. Louis does not like killing humans, but Lestat continually pushes him to do so. One night Louis comes across a young girl named Claudia who he cannot resist biting.

Lestat stops Louis before he kills Claudia and changes her into a vampire. Louis hates Lestat for taking away the young girls mortal life and threatens to leave. Lestat then convinces Louis that he must stay in order to help raise Claudia. Since Louis does not want to see Claudia end up as ruthless as Lestat he remains to help take care of the young vampire. Ultimately, Claudia learns that it was Lestat who made her into a vampire and she resents him for trapping her in a childs body eternity, as well as his refusal to tell her about other vampires. Claudia attempts to kill Lestat twice so she and Louis can leave him, and find other vampires in the world.

The two head to Europe because that is where they originated in myths. In Europe Louis and Claudia find a group of vampire who are led by the oldest living vampire, at least to his knowledge, Armond. Eventually Armond grows to love Louis and has Claudia killed, because he is jealous of all the attention she gets from Louis and because she tried to kill Lestat. Louis does not know that Armond is responsible for Claudias demise and returns to Louisiana with Armond to learn more about his powers. After Armond tells Louis that he was responsible for Claudias death Armond leaves him and Louis runs into Lestat, who is know old and afraid to leave the house. After hearing the story the interviewer says he wants to become a vampire but Louis does not change him.

The interviewer then sets off in search of Lestat.