Mortgage Expo Com example essay topic

Viola ine Simon, Salina Mhaouty-Koda, Chantal Legrand and Jo " elle Cohen-Tannoudji Laboratoire de Physiologie de la Reproduction, ESA Centre National de la Recherche Scientifique 7080, Universit'e Pierre et Marie Curie, 75252 Paris CEDEX 05, France Address all correspondence and requests for reprints to: Jo " elle Cohen-Tannoudji, Laboratoire de Physiologie de la Reproduction, ESA Centre National de la Recherche Scientifique 7080, Universit'e Pierre et Marie Curie, 4 Place Jussi eu, 75252 Paris CEDEX 05, France. E-mail: . The myometrial ss-adrenergic receptor (ss-AR) -adenylyl cyclase pathway is markedly desensitized at the end of pregnancy in the rat. We have investigated whether changes in the amount and / or the activity of G protein-coupled receptor kinase (GRK) occurred at the same period of pregnancy.

Using Northern and Western blotting, we have identified GRK 2, GRK 5, GRK 6, and a small amount of GRK 3 in late pregnant rat myometrium. GRK activity, as measured by in vitro phosphorylation of rhodopsin, was detected in both cytosolic and plasma membrane fractions. Interestingly, in the 6-10 h preceding parturition, there was a substantial increase (+190%) of myometrial membrane-associated GRK activity. This was associated with an increase in membrane GRK 2 immunoreactivity. Such alterations occurred concomitantly with uncoupling of ss-AR, as assessed by quantification of high-affinity binding receptors. These data suggest that GRK activity increase may be one of the mechanisms underlying alterations in the coupling between ss-AR and adenylyl cyclase and may thus contribute to the initiation of myometrial contractions at term.

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