Treatment Of Huntington's Disease example essay topic

Huntington's Disease Huntington's disease, or Huntngton's chorea, is a genetic disease that causes selective neural cell death, which results in chorea, or irregular, jerking movements of the limbs caused by involuntary muscle contractions, and dementia. It can cause a lack of concentration and depression. It also may cause atrophy of the caudate nucleus, a part of the brain. However, symptoms vary between individuals, with some sufferers showing symptoms that others do not. Those suffering from Huntington's disease normally begin displaying symptoms between the ages of 30 and 50, but has been known to show itself in people as young as two and as old as 80. Huntington's disease is from one of the victim's parents.

Since the gene for HD is dominant, there is a 50% chance of a sufferer's offspring inheriting the disease. Because a victim usually does not begin to display symptoms until after the period in which he or she would have children and the disease may have been misdiagnosed in earlier generations as Parkinson's disease or other similar affliction, he or she might pass along the gene without even knowing it. The gene for Huntington's disease is located on the short arm of chromosome four in cytogenetics band 4 p 16.3. It was first identified in 1993. While everyone possess this gene, in someone suffering from Huntington's disease, the number of repeats of a certain tri nucleotide, cytosine-adenine-guanine (CAG), is much larger than what it is in a normal person. In an average person, the number of repeats is between 9 and 37.

But is a sufferer of HD, the repeat count is from 37 to 86. While nobody has found a direct correlation between the number of repeats and the age when symptoms appear, there is evidence that people with very high numbers of repeats contract the rarer early-onset Huntington's disease, which usually affects people under the age of 20. It is estimated that between. 1 and 10% of people who suffer from Huntington's disease have obtained it through new mutations.

There are three different tests for Huntington's disease. The first, pre symptomatic testing, is for people who are at risk for the disease. The second, prenatal testing, is a testing of a fetus at risk for the disease. The third type of testing, confirmatory testing, is used on someone suspected of having Huntington's disease. Treatment of Huntington's disease usually involves council ing and education about the disease of both the family and the patient. Since the symptoms are so varied in both type and severeness from patient to patient, medical treatment must be individualized.

Depression, a common symptom, is usually treated with tricyclic antidepressants. Those that also show obsessive compulsive behavior may take some types of agents. Neuroleptic's, or drugs that block dopamine receptors, are useful in the treatment of chorea. It has been suggested that treatment with nerve-growth producing agents may be an affective treatment, but research is still being conducted. Procedures such as, or removing part of the globus pallid us, , or cutting part of the thalamus have both showed promising results in the treatment of the involuntary movements and tremors in Parkinson's disease and may also help sufferers of Huntington's.

Fetal brain tissue transplantation has also helped in Parkinson's disease patients. While there has been a few of these transplantation's performed on HD patients, it is still too early to evaluate its success. Since the huntington pro tien causes a gain of function instead of a loss of function, normal gene therapy techniques normally do not work. Instead, must be removed or its gain of function effects must be inhibited.

Currently, the second approach makes more sense, since we already know how the huntington protein interacts with other proteins and we can, through this knowledge, find modulators to treat the disease. In conclusion, Huntington's disease is a degenerative disease of the mind and body. It ultimately causes death. While current treatments can only help the symptoms, it is hoped that further research and new techniques will bring about an effective cure. Web Sites Used Baylor College of Medicine- Information on Huntington's Disease web Huntington's Disease Society of America- Northeast Ohio Chapter web's Disease Information web for People With Huntington's Disease web.